A colleague asked me about the statistical methods in this paper, which is available for public download from JAMA network open.
I'd appreciate suggestions from section members - for relevant citations to publications , or youtube lectures describing
Mendelian Randomization methods.These are entirely new to me.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2790520
Biddinger, Kiran J., et al. "Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease." JAMA Network Open 5.3 (2022): e223849-e223849.
excerpting from the articleEfforts to address this complex association through a randomized clinical trial have been met
with logistical and ethical challenges, culminating in the discontinuation of a trial of modest alcohol
consumption led by the National Institutes of Health.12 In the absence of a randomized trial, a
technique using human genetic data (ie, mendelian randomization [MR]) has enabled assessment for
potential causal associations by leveraging naturally occurring genetic variants as unbiased proxies
for an exposure (ie, alcohol intake).13 Given the random allocation of genetic variants at conception,
MR obviates concerns of confounding and reverse causality, 2 key limitations of observational
epidemiology.
Thank you
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Chris Barker, Ph.D.
2022 Statistical Consulting Section
Chair-elect
Consultant and
Adjunct Associate Professor of Biostatistics
www.barkerstats.com---
"In composition you have all the time you want to decide what to say in 15 seconds, in improvisation you have 15 seconds."
-Steve Lacy
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