Dear Laila
Good text books to start you off are:
Bayesian Adaptive Methods for Clinical Trials by Berry, Carlin, Lee and Muller
Adaptive Design Methods in Clinical Trials by Chow and Chang
The DIA Adaptive Design Scientific Working Group published a series of papers in 2006 (when it was still under PhRMA auspices). A good summary paper is:
Adaptive Designs in Clinical Drug Development - an Executive Summary of the PhRMA Working Group by Gallo et al, Journal of Biopharmaceutical Statistics, 16: 275-283, 2006
But there were also a series of papers in the Drug Information Journal that year.
I would also recommend reading:
Good Practices for Adaptive Clinical Trials in Pharmaceutical Product Development, Gaydos et al, Drug Information Journal, Vol. 43, pp. 539-556, 200
If you want to specifically focus on dose ranging then read the paper:
Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials, Bornkamp et al, Journal of Biopharmaceutical Statistics, 17: 965-995, 2007
Others may have suggestions but I think this is a good start.
Kind regards
Alun
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Alun Bedding
Principal Statistical Scientist
Roche Products Ltd
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Original Message:
Sent: 04-16-2014 10:16
From: Laila Poisson
Subject: Recommendations for learning adaptive trial design?
Hi Everyone,
I'm trying to come up to speed on adaptive trial design. Do any of you have textbooks or papers that you would recommend? I'm looking to get a good foundation in the theory so I can critically assess new methods and fit them to our needs.
Many thanks!
Laila
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Laila Poisson
Biostatistician
Henry Ford Health System
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