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  • 1.  Comparing before and after scores based on questionairre

    Posted 06-18-2012 17:11
    Dear All,

    Can anyone please suggest an appropriate test for testing if there is significant difference in the scores obtained at two different time points of 500 patients(based on some standard questionnaires, where each questionnaire has around 5 -10 questions and each question is assigned some points between 1-5).

    PS: We also have some missing values since not every patient who answered the questionnaire at time t1 responded at the follow up time t2.

    Any suggestions will be appreciated.

    Best Regards,
    Tasneem

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    [Tasneem] [Zaihra]
    [Assistant Professor]
    [Concordia University]
    [Montreal]
    [QC]
    [Canada]
    -------------------------------------------


  • 2.  RE:Comparing before and after scores based on questionairre

    Posted 06-18-2012 23:08
    Tazneem,
    How about the signed-rank test, applied to the change in the patients' questionnaire scores between t1 and t2?   

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    Eric Siegel
    Biostatistician
    Univ of Arkansas for Medical Sciences
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  • 3.  RE:Comparing before and after scores based on questionairre

    Posted 06-19-2012 12:36
    Thanks Eric and Steven for your input. It's much appreciated.
    Best Regards,
    Tasneem

    -------------------------------------------
    [Tasneem] [Zaihra]
    [Assistant Professor]
    [Concordia University]
    [Montreal]
    [QC]
    [Canada]
    -------------------------------------------








  • 4.  RE:Comparing before and after scores based on questionairre

    Posted 06-19-2012 08:36
    Before you start doing longitudinal analyses, you should first make sure that you can extract a meaningful measurement from each questionnaire. Taking the sum of the items might (or might not) produce a coherent, unidimensional measurement, so that should be explicitly tested. Establish that the measure has reliability and validity at the pre-test, then confirm that the same measurement structure applies at the post-test before you worry about longitudinal comparisons. Such comparisons are only sensible if a given score has the same meaning at each time point. You can use confirmatory factor analysis and structural equation modeling to investigate these issues.

    Assuming the scores end up properly being continuous, then a simple paired t-test could answer your primary question, as could a variety of other statistical methods.


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    Steven Pierce
    Associate Director
    Center for Statistical Training and Consulting
    Michigan State University
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  • 5.  RE:Comparing before and after scores based on questionairre

    Posted 06-20-2012 13:27
    Tasneem, 

    I cannot agree more with Steven's insightful inputs. Given that most health-related instruments/scales/surveys/constructs/questionnaires were NOT 'professionally developed' and 'few of them have received much critical evaluation' (Teresi & Fleishman 2007), it is essential to test the basic psychometric properties (reliability, validity, etc) of these instruments/questionnaires, even though for those claimed as 'standard' ones, which in fact never exist for your own sample before testing ("Validity", Zumbo 2007).

    Back to your data, for a questionnaire with 5-10 questions, with each has a 1-5 Likert-type response, it is crucial to test at least the following 2 things, for each of the two time points you have (Pre-, and Post-): 

    1. Can the individual scores from each of these 5-10 questionnaires be summarized into a single 'Total Score'? The big assumption behind this single 'Total Score' is the 'unidimensionality', i.e., each and all of the 10 questions is measuring the single same thing('Construct', e.g., Happiness, Stress, Satisfaction, etc). To test this assumption, you need to run a Confirmatory Factor Analysis (CFA). And when you run this CFA, please keep in mind that your data are actually ordinal, not continuous. (Moreover, although rarely addressed, Longitudinal Measurement Invariance (Brown 2006) is actually another assumption needed for meaningful Pre-/Post- comparison of data like yours). 

    2. How 'reliable' the questionnaire is, especially, how 'internally consistent' the 10 questions are? This can be assessed by the Cronbach's Alpha (Cronbach 1951). And if possible, you might also want to test reliability using other methods, such as Test-Retset, Alternative-Form, Split-Haves, and you might want to read Cmrmines & Zeller's classic booklet (SAGE, 1979) on this topic.

    After passed these two basic tests, the ordinary biostatistical techniques come in, and it's totally up to you to make a choice from many different options.   

    Sincerely yours,

    Chengwu Yang (杨成武)
    ______________________
    Chengwu Yang, MD, MS, PhD
    Assistant Professor of Biostatistics
    Department of Public Health Sciences
    College of Medicine, The Pennsylvania State University
    A210, ASB 3400H, 600 Centerview Drive, Hershey, PA 17033
    Email: yangc@psu.edu; Phone: 717-531-3016; Fax: 717-531-0146
    http://profiles.psu.edu/profiles/ProfileDetails.aspx?From=SE&Person=244

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  • 6.  RE:Comparing before and after scores based on questionairre

    Posted 06-21-2012 08:18
    I agree that the CFA Chengwu mentioned should probably treat the items as ordinal data, but then that means that using Cronbach's alpha to assess reliability is thoroughly inappropriate. In that case, use the methods by Green & Yang (2009) instead.


    Green, S. B., & Yang, Y. (2009). Reliability of summed item scores using structural equation modeling: An alternative to coefficient alpha. Psychometrika, 74(1), 155-167. doi: 10.1007/s11336-008-9099-3 

    -------------------------------------------
    Steven Pierce
    Associate Director
    Center for Statistical Training and Consulting
    Michigan State University
    -------------------------------------------








  • 7.  RE:Comparing before and after scores based on questionairre

    Posted 06-22-2012 09:02

    Good point, Steven. Thanks for the reminder. Another solution is to calculate the 'Ordinal Version' of Cronbach's alpha for Likert data based on the polychoric correlation matrix: 

    Zumbo, B. D. G. A. M. &. Z. C. (2007). Ordinal versions of coefficients alpha and theta for Likert rating scales. Journal of modern applied statistical methods, 6, 21-29

    Sincerely yours,
    Chengwu Yang