That ISPOR Task Force Report on Indirect Treatment Comparisons referenced by Dr. Barker? It has a "Part 2" companion report, located at:
http://www.sciencedirect.com/science/article/pii/S1098301511013283
Also, here is the PubMed abstract of an application of network meta-analysis to comparing overall survival between different RCTs in the melanoma context:
http://www.ncbi.nlm.nih.gov/pubmed/23024154
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Eric Siegel, MS
Research Associate
Department of Biostatistics
Univ. Arkansas Medical Sciences
Original Message:
Sent: 07-22-2016 12:55
From: Chris Barker
Subject: Estimating a relative treatment effect
Health economists (and others) like methods of "indirect comparison"
I'm generally skeptical of methods that compare groups that weren't randomized..
https://www.ispor.org/workpaper/interpreting-indirect-treatment-comparison-and-network-meta-analysis-studies-for-decision-making.pdf
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Chris Barker, Ph.D.
Consultant and
Adjunct Associate Professor of Biostatistics
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"In composition you have all the time you want to decide what to say in 15 seconds, in improvisation you have 15 seconds."
-Steve Lacy
Original Message:
Sent: 07-22-2016 11:33
From: Shelley-Ann Walters
Subject: Estimating a relative treatment effect
Does anyone know of a method to get an estimate of hazard ratios (HR) of Treatment A to Treatment B from literature, when we have estimates of Treatment A to control from one study and Treatment B to the same control in a separate study?
The 2 studies were run by the same investigator and have the same design. The responses for the control group in the 2 studies were almost identical (1.29 / 1000 days in Study 1 and 1.3 /1000 days in Study 2), which gives me confidence in combining the data from the 2 studies. I have estimates of the HR compared to control from both studies, 95% CIs for the estimates, and sample sizes.
Can I combine the data to get an estimate and 95% CI for HR of A/B?
Thank you.
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Shelley-Ann Walters
Biostatistical Specialist
3M Health Care Business
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