This message has been cross posted to the following eGroups: Statistical Consulting Section and Biopharmaceutical Section .
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A question for those with toxicology study expertise.
I was presented with the analysis results of a QT/QTc study in Cynologous "cyno" Monkeys .
The design used a Latin square. I've designed and analyzed Latin square studies in the past.
This study, had 4 treatments and 3 active tx,and a placebo group, and four periods.
I also discovered, that the study had enrolled 4 (four) total animals, one animal per sequence. Its not clear from the report if these were randomly assigned. And within each period the animal was measured about 6 times .
The analysis was then prepared with proc mixed (SAS). The mixed model had treatment, time and animal in the model. A number of large and statistically significant QT effects (treatment vs. placebo) were detected.
is this "typical" for a QT/QTc study in monkeys to have only one animal per sequence? .
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Chris Barker, Ph.D.
Consultant and
Adjunct Associate Professor of Biostatistics
www,barkerstats.com
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"In composition you have all the time you want to decide what to say in 15 seconds, in improvisation you have 15 seconds."
-Steve Lacy
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