Dear Colleagues,
I'm interested in knowing if there's a way to compute the sample size required for designing a superiority trial using PASS and nQuery Advisor? The manuals for both packages are not very clear on computing this for a superiority trial. The indexes also do not list 'superiority' in their list of key words to be able to find easily.
Design of the Trial: There are three treatment groups - one is current standard of care (SOC), and the other two groups are two different doses of the new treatment. The end point being measured is binary and higher rates indicate success and therefore, is desired.
Current Assumptions: Desired Power = 0.8, Type I Error Rate = 5%, Proportion of Success in SOC arm = 0.9, Proportion of Success in New Treatment arm = 0.95 (regardless of dose).
Any insights would be greatly appreciated.
Thank you,
Sincerely,
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Mamtha Balasubramaniam
Sr. Biostatistician
Beaumont Hospitals
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