Traditional Weighted Random Effects Meta-Analysis Practice Must Change.
When a major discovery is made about statistical practice, it needs to be translated into practical application. The enclosure is a poster child for this concept, as in two independent ways, it points you to the fact that the current mainstream methods in random-effects meta-analysis of collections of randomized clinical trials (the apex of most evidence pyramids) are not based on sound statistical science. It also provides a distribution-free alternative and user-friendly well-tested software to do the calculations.
Use of the mainstream methods has resulted in adverse public health policy decisions and continued use will likely continue to do this in the future.
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Jonathan Shuster
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