Title: Efficiency and Estimation for Adaptive Designs with Unblinded Sample Size Re-estimation
Presenter: Cyrus R Mehta
Date and Time: Thursday, May 24, 2018, 12:00 p.m. – 1:00 p.m. Eastern time
Sponsor: Section on Medical Devices and Diagnostics
Registration Deadline: Tuesday, May 22, at 12:00 p.m. Eastern time
Clinical trials with adaptive sample size re-assessment, based on an analysis of the unblinded interim results have gained in popularity due to uncertainty regarding the value of δ at which to power the trial at the start of the study. In implementing such designs one must address three statistical issues:
- How to control the type-1 error
- How to construct an optimal decision rule for increasing the sample size
- How to estimate δ at the end of the study
In this presentation I will address all three issues.
Member of the Section for Medical Devices and Diagnostics (MDD): $40
ASA Member: $65
Each registration is allowed one web connection. Sound is received via audio streaming from your computer’s speakers. Multiple persons are encouraged to view each registered connection (for example, by projecting the webinar in a conference room).