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Final Reminder: WTASA Short Course with Shu Yang - Hybrid Controlled Trials | Aug. 14

  • 1.  Final Reminder: WTASA Short Course with Shu Yang - Hybrid Controlled Trials | Aug. 14

    Posted 7 days ago

    Title:
    This Friday: WTASA Short Course on Hybrid Controlled Trials with External Controls | Shu Yang | Aug. 14

    πŸŽ₯ Cannot attend live? All registrants will receive the course recording and slides/materials afterward.

    Dear colleagues,

    A friendly reminder that the Western Tennessee ASA Chapter (WTASA) will host our upcoming short course this Friday, August 14, featuring Professor Shu Yang of North Carolina State University.

    Speaker: Professor Shu Yang, North Carolina State University
    Date: Friday, August 14, 2026
    Time: 2:00–5:00 PM Central Time
    Format: Online via Zoom
    Registration fee: $20

    πŸ” Topic

    Hybrid Controlled Trials with External Controls:
    A Bias-Aware Frequentist Toolkit for Design, Analysis, and Software

    External controls and hybrid controlled trials are becoming increasingly relevant in settings such as rare diseases, pediatric trials, small populations, and studies where conventional randomized control groups may be difficult to implement.

    At the same time, borrowing external information introduces important statistical challenges, including covariate shift, outcome drift, hidden bias, and type I error control.

    Professor Yang has developed a focused three-hour course that brings together methodological foundations, practical examples, a case study, open-source software demonstrations, and interactive discussion.

    🎯 Participants will learn to:

    β€’ Understand external controls and hybrid controlled trials and identify settings where they may be particularly useful.
    β€’ Recognize covariate shift and outcome drift as two major sources of bias when incorporating external data.
    β€’ Compare bias-aware frequentist approaches, including test-then-pool, bias-function modeling, and semiparametric selective borrowing.
    β€’ Learn randomization-based inference and conformal selective borrowing approaches designed to maintain type I error control, including in small trials.

    πŸ•’ Course schedule

    2:00–4:00 PM: Frequentist methods

    β€’ Gold Standard's Limits
    β€’ Borrowing Data, Risk
    β€’ Statistician's Toolkit
    β€’ Small Trial Confidence
    β€’ A Smarter Clinical Trial

    4:00–5:00 PM:
    Case study, software demonstrations, and interactive learning

    πŸ’΅ Registration

    Registration fee: $20

    PayPal registration link:

    https://www.paypal.com/ncp/payment/ACGXXEE3R3JU6

    The Zoom link will be emailed to registered participants before the course.

    One of our goals at the Western Tennessee ASA Chapter is to create a platform for our community to continuously learn, exchange ideas, and stay connected with emerging statistical methods and technologies, particularly those relevant to biostatistics, clinical research, and medicine. We hope this short course contributes to that goal.

    Whether your work involves clinical trials, biostatistics, pediatric research, rare diseases, real-world evidence, or causal inference, we hope you will join us this Friday.

    We look forward to learning together!

    Organized by:
    Western Tennessee ASA Chapter (WTASA)

    WTASA Executive Committee:
    Haitao Pan, President
    Yiwang Zhou, Vice President
    Yuan Zhang, Treasurer
    Kendrick Li, Secretary
    Xueyuan Cao, Student Representative
    Xichen Mou, Council of Chapters Representative

    Best regards,
    Haitao Pan, PhD
    President, WTASA



    ------------------------------
    Haitao Pan
    Associate Professor
    St. Jude Children's Research Hospital
    ------------------------------


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