Hi all,
The ASA San Antonio Chapter will host a virtual seminar on Friday, April 17, at 11 AM CST. If your schedule allows, we warmly invite you to join and support this chapter event.
Detailed seminar information is provided below.
Thank you very much, and we hope to see you there!
ASA San Antonio Chapter Virtual Seminar
"Bayesian Monitoring Designs with Multiple Endpoints for Phase II Clinical Trials"
Dr. Jian Wang
Associate Professor
Department of Biostatistics
The University of Texas MD Anderson Cancer Center
Friday, April 17, 11 am CST
Zoom: https://utsa.zoom.us/j/96644803413
Abstract: To evaluate the preliminary therapeutic effect of a new treatment, futility monitoring rules are commonly used in phase II cancer clinical trials to make timely "go/no-go" decisions. Standard approaches typically rely on a single endpoint, which may not adequately capture treatment effects when multiple outcomes are clinically relevant. In this talk, I present two Bayesian monitoring approaches that incorporate multiple outcomes in different settings. For single-arm trials, a hierarchical model integrates response and duration of response into the monitoring rule. For randomized two-arm trials, a win ratio–based framework enables hierarchical comparison of multiple time-to-event outcomes while accounting for their clinical priorities. Simulation studies illustrate that leveraging multiple outcomes can lead to more informed and tailored decision-making compared to conventional single-endpoint designs.
Bio: Dr. Jian Wang is an Associate Professor in the Department of Biostatistics at The University of Texas MD Anderson Cancer Center. She received her PhD in Statistics from the University of Colorado Boulder and completed postdoctoral training in statistical genetics and cancer epidemiology at MD Anderson. Her research focuses on the development and application of statistical methods in statistical genetics, cancer epidemiology, clinical trials, and behavioral research. For more information, please visit her website: https://faculty.mdanderson.org/profiles/jian_wang.html.
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Yuexia Zhang
Assistant Professor
Department of Statistics and Data Science
The University of Texas at San Antonio
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