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American Statistical Association

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  • Virtual lunchtime meeting

    Join the Central Indiana Chapter for a virtual lunchtime meeting where our guest speaker will be Dr. Giorgos Bakoyannis from the Department of Biostatistics at the IU School of Medicine.
     
        date: Tuesday, February 04, 2025
        time: Noon - 1:00 ET
     
    title: Estimating optimal individualized treatment rules with multistate processes
     
    abstract:
    Multistate process data are common in studies of chronic diseases such as cancer. These data are ideal for precision medicine purposes as they can be leveraged to improve more refined health outcomes, compared to standard survival outcomes, as well as incorporate patient preferences regarding quantity versus quality of life. In this work, we propose a nonparametric outcome weighted learning approach for this problem in randomized clinical trial settings. The theoretical properties of the proposed methods, including Fisher consistency and asymptotic normality of the estimated expected outcome under the estimated optimal individualized treatment rule, are rigorously established. A consistent closed-form variance estimator is provided and methodology for the calculation of simultaneous confidence intervals is proposed. Simulation studies show that the proposed methodology and inference procedures work well even with small-sample sizes and high rates of right censoring. The methodology is illustrated using data from a randomized clinical trial on the treatment of metastatic squamous-cell carcinoma of the head and neck. Finally, we present an extension of the methodology for observational data where confounding and dependent right censoring are common.
     
    speaker:
    Giorgos Bakoyannis is an Associate Professor in the Department of Biostatistics and Health Data Science at Indiana University Indianapolis, where he also serves as the Director of Public Health Science Research. His methodological research focuses on precision medicine, specifically the development of methods for estimating optimal individualized treatment rules, and causal inference. Dr. Bakoyannis’ expertise also includes the nonparametric and semiparametric analysis of complex event history data, with a particular emphasis on challenges commonly encountered in biomedical and clinical research, such as missing data, misclassification, and interval censoring. His work has been published in leading statistical and biostatistical journals, including Biometrics, Biostatistics, and Statistica Sinica. Dr. Bakoyannis has received several awards from the American Statistical Association, the International Biometric Society – Eastern North American Region, and the International Chinese Statistical Association. He has also received funding from the National Institutes of Health (NIH) as a Principal Investigator to conduct methodological research.
  • Chapter Networking Event

    *****
        What:  Chapter networking event
        When:  Thursday, August 22, 2024
                     4:00 pm - 6:00 pm ET
        Where: 317 BBQ
                     6320 Guilford Ave
                     Indianapolis, IN 46220
        It's Free!:  register on eventbrite
        
    Join your fellow Central Indiana Chapter members in Broad Ripple on Thursday, August 22, 2024 for a professional networking event. We are teaming up with C|Spring (a consulting firm specializing in data analytics and information management strategies) to host this casual, after-work get-together. There will not be a speaker or seminar. The purpose of the event is to mingle and converse with your fellow statisticians and data science professionals from central Indiana. Light food and beverages will be served. The event is FREE, but you need to register to attend. 
     
    If you have any questions or would like more information about this event, please contact our chapter president Meghan Tooman (meghan@dorisresearch.com).
     
    *****

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