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kronecker product covariance structure using lme/R

  • 1.  kronecker product covariance structure using lme/R

    Posted 03-03-2017 20:38
    Dear  all,
    I am trying to fit mixed effect model  for nested repeated measurement data in R using lme with composite convariance structures  A@B such as: Unstructured with Autoregressive UN@AR(1) [ kronecker product].

    The following is the nested repeated measurement model:
    nested.lme=lme(Y~Time,data=df, random=~Time|Visit/ID, na.action=na.exclude, method='ML')
     
    How can I fit the previous model with kronecker product in lme ?

    Thank you in advance for your cooperation.

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    Enas Ghulam
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