Two Diseases Whose Rates Warranted Aggressive Search and Rescue in Puerto Rico Post Maria
The CDC publishes rates of diseases by States (including U.S. territories, such as Puerto Rico) and even counties within states. These publications of disease rates are published in the Mobidity and Mortality Weekly Reports (MMWR). Two diseases, forms of diabetes (both Type 1 and Type 2) and End Stage Renal Disease (ESRD), are medical conditions that require monitoring and intervention. ESRD requires dialysis or a kidney transplant for survival and diabetes accounts for 66% of ESRD patients (Burrows, et al., MMWR, March 3, 2014). Diabetes is often co-morbid with a number of medical conditions and is the third leading cause of death in Puerto Rico (PR), as is found in the United States, in general (Puerto Rico Chronic Disease Action Plan 2014-2020). Below are other references (in shorthand), including references not from MMWR reports, with some data from each reference that highlight the need for aggressive search and rescue to ensure health maintenance in times of crisis, such as Hurricane Maria and its aftermath. Some of the computations are rounded because of ease and the changing numbers of the population on Puerto Rico.
Geis, et al., (MMWR, Nov 16, 2012) 12.7% of adults greater than 18 on PR have diabetes. Given 3.3 million residents on PR and that those greater than 18 account for approx. 80% of the population (Wikipedia for PR) .8 x 3.3 million x .127 = 335, 280 (approx.) people with diabetes on PR.
Cumba-Aviles & Saez-Santiago (Rev Puertorriquena, 2016, 27, 44-60). For PR, estimates of diabetes from 2011-2013 are 13.3% to 16.4%. Of those less than 20 years old, about 16,148 have diabetes, with the presumption most of this number are Type 1 diabetics (page 3).
Salas, et al. (PLOS|One, 2016) For PR, among the elderly (>65), 37.1% are diabetic. Given there are 582,036 elderly in PR (https://en.wikipedia.org/wiki/Demographics_of_Puerto_Rico)
, there are .371 x 582,036 = 215,935 elderly with diabetes (approx.) on PR. Approx. 5% of diabetics are Type 1 (https://www.cdc.gov/diabetes/basics/type1.htm), so, .05 x 215,935 = 10,797 (approx..) Type 1 diabetics among the elderly.
Salas, et al. estimate (see Figure 1) that 15% are diagnosed and controlled and approx. 17% are diagnosed and uncontrolled. Thus .32 x 215,935 = 69,099 that are diagnosed. Salas, et al. state that 25% of those treated receive insulin and that 90% receive either insulin or hypoglycaemic agents (for example, Metformin). So, .25 x 69,099 (approx.) = 17,275 (approx..) receive insulin and .90 x 69,099 = 62,189 (approx..) receive insulin or hypoglycaemic agents.
The total approx.. diabetics receiving insulin: 16, 148 (under 20) + 17,275 (over 65) + (over 20 and Under 65) + 12,148 (see computation below) = 45, 571 Type 1 diabetics in PR (approx..)
PR (https://en.wikipedia.org/wiki/Demographics_of_Puerto_Rico
65.36% (15-64) – 7.39% (15-19) = 57.97 of the population
.5797 x 3.3 million x .127 = 242,952 (approx..) diabetics (20 to 64 in PR) x .05 = 12,148 Type 1
As far as ESRD:
Burrows, et al (Burrows, et al., MMWR, March 3, 2014) In PR in 2010, there were 6,091 patients over 18 with 1,462 starting treatment in 2010. Previously, 867 patients treatment for ESRD in 2007 (MMWR, October 29, 2010)
Sheri Fink (2018, Washington Post letter) cited Santos-Lozado and Howard (unpublished manuscript) , who estimated that given the 95th percentile for the computed confidence interval of deaths between 2010 to 2016, that there were 518 excess deaths in September and 567 deaths in October.
The subsequent estimates from Harvard (which I don't think looked at excess deaths) and the GW study (which did look at excess deaths) had death estimates in the thousands (4,000 approx. for Harvard and 3,000 approx. for GW Milken Center).
Given, the thousands of patients requiring access to electricity (insulin refrigeration and dialysis treatment and medication. e.g. Metformin, kept at room temperature) for just the two medical conditions, that are awkwardly presented above, how can one logically assert that only three score people succumbed to the harsh conditions that the population in Puerto Rico endured for months, if not for more than half a year? Were a number of those vulnerable flown to safety? How many? Were a number of those vulnerable treated on the Ship Comfort. With 200 empty beds on the Ship, one logically wonders. Were there search and rescue efforts to rescue patients in hospitals without electricity and from the countryside? If so, again, why were the beds empty? Were there any considerations of prevalence rates of medical conditions, such as the two discussed in the present letter, and many other critical medical and psychological conditions that the CDC could have provided? If there were consideration of accessed prevalence rates, what was done? Again, there were 200 empty beds on the Ship Comfort, as repeatedly reported in the news.
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Mark Czarnolewski
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Original Message:
Sent: 09-15-2018 15:32
From: Ronald LaPorte
Subject: counting hurricane deaths in Puerto Rico
Dear Giants of Statistics,
I would appreciate your statistical input to me, an epidemiologist.
A few days ago Trump indicated that there were only 64 deaths my Maria in Puerto Rico, despite two studies suggesting 2715 (GW) and 4645 (Harvard). I became interested in this huge variation. Quite clearly the number of deaths exceed 64. However, as I dug deeper in the other studies, it seemed that the GW and Harvard estimates were very high. I wanted to lay out my finding to see what you think, and what type of studies could be done to get better estimates. What I discovered is that the estimates of "Death by Hurricane" are extremely variable. Here are the GW and Harvard estimates. Both have problems
https://publichealth.gwu.edu/sites/default/files/downloads/projects/PRstudy/Acertainment%20of%20the%20Estimated%20Excess%20Mortality%20from%20Hurricane%20Maria%20in%20Puerto%20Rico.pdf
https://www.nejm.org/doi/full/10.1056/NEJMsa1803972
Here is what stimulated my interest
Hurricane # Deaths
Puerto RIco 4645
Puerto RIco 2715
Katrina 283-1836
Audrey 418
Sandy 230
Harvey 82
Hugo 34
florence 5
I find it very hard to believe that maria was 2-3 times as dangerous a Katrina.
2. Previous studies mentioned that 40 to 70% of the deaths from Hurricanes are due to drowning due to the storm surges. The numbers of deaths for drowning is very low in Puerto rico, I could not find information find what happened after the hurricane, but it is hear where most of the excess deaths would be seen. Even if there was a 10 fold increase in drowning death, this would not bring the estimates even close to ~3000
3. the GW study postulates that the excess deaths were not found because of poor death certificate coding. This is difficult to believe, as the increase in deaths would be located with drowning and injuries, both of which would be picked up. Also, for this was the cause, then 99% of the deaths due to the hurricane would have to be miscoded to account for the excess. The PR health department of doctors would never be this bad. Finally, if there were 3000-5000 deaths during this period it would be obvious as as people would be "dying in the streets", something we saw with Katrina. THis really does not make sense
4. A primary reason for this is that it is difficult to classify a hurricane related death. This is an interesting article indicating that we still do not have a firm figure about deaths . https://fivethirtyeight.com/features/we-still-dont-know-how-many-people-died-because-of-katrina/?ex_cid=538twitter Much of the variation can be explained through this.
6. The approached used in the GW study are suspicious for me as an epidemiologist. They estimate the rates and numbers of total mortality before the hurricane, and then during it. This type of analysis is call an ecologic analysis, and quite problematic for epidemiologist like me. THe reason is that this is a pure correlation analysis and not adequate for testing specific hypotheses. Other things could be changing rapidly as well, e.g. the opiate epidemic, rapidly changing economic conditions. I will not feel comfortable until I see the changes in the cause specific deaths, especially the change in drowning death.
Another issue is that there was a suggestion of increased mortality due to diabetes. I am one of the world's experts on diabetes epidemiology, and seriously doubt that the storm could speed the death of people with diabetes. I do not know of any data to support this.
Thus I agree that the number of deaths is greater than 64. However, I really find it hard to believe that this was 2-3 times as deadly at Katrina
I would love your thoughts
ron
"Health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity". (WHO)
Ronald LaPorte, Ph.D.
Professor Emeritus, former WHO Collaborating Centre
Department of Epidemiology
Graduate School of Public Health
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University of Pittsburgh
Pittsburgh, PA 15261
USA
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