The Mathematical Biosciences Institute (MBI) at The Ohio State University is hosting a free online colloquium given by Elizabeth Thompson, Department of Statistics, The University of Washington. Her presentation will be streamed live beginning at noon EST on Wednesday, November 9, 2016. See the advertisement below for more information on her talk and instructions for connecting to the live stream.
The Mathematical Bioscience Institute
National Mathematical Biology Colloquium
This online series gives individuals and groups the opportunity to watch talks and to interact with distinguished speakers. Details of how to connect to the talks are available on the MBI website at https://mbi.osu.edu/go/n/colloquium.
The colloquium series continues tomorrow with:
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Wednesday, November 9, 2016 at Noon Eastern Time
ELIZABETH THOMPSON
Professor, Department of Statistics, University of WashingtonFinding Genes via Relatedness and the Co-ancestry of Genome |
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A major goal of genetic analysis is to find the genes that underlie traits of medical or economic importance. The associations between trait data and marker DNA arise from the descent of genome to related individuals. Thus, we consider these associations through analyses of relatedness as measured by shared ancestry of genome, or identity by descent (IBD). To achieve this, we present models for IBD both among individuals and across the genome, and thence a framework for realizations of IBD given genome-wide marker data. In general, model-based probabilities of trait data jointly on individuals depend only on the joint IBD among them at the relevant loci. We consider the particular case of a variance component model for a quantitative trait, where only location-specific pairwise relatedness between individuals is required.
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Catherine Calder
The Ohio State University
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