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May 2012

May 21, 1:00 PM - 3:00 PM
Online Web Presentation, US

May 23, 2:00 PM - 3:00 PM
Clinical Research Building
Miami, FL, US
Leslie McClure from the University of Alabama at Birmingham (UAB) will be presenting a seminar on 5/23/12 at 2:00 p.m. in CRB 988.

Abstract:

Lessons Learned from an On-Going Clinical Trial: The SPS3 Experience

 The Secondary Prevention of Small Subcortical Strokes (SPS3) study is an on-going clinical trial assessing the efficacy of two interventions for preventing recurrent strokes.  Participants are randomized in a 2x2 factorial fashion to receive either combination antiplatelet therapy or aspirin alone, and to receive blood pressure lowering interventions with goals of lower systolic blood pressure to one of two target ranges.  During the conduct of the study, several interesting statistical issues have arisen.  In this talk, I will focus on the operating characteristics of two of these issues.  First, I will discuss the approach we took to monitor futility in this 2x2 factorial study.  I will describe the properties of our method, compared to other ways to monitor futility in this situation. Second, I will discuss a mid-study modification that was made to the sample size, due to a lower than expected observed overall event rate during the course of the study.  I will focus on the impact of the design modification on overall power and Type I error.



May 23, 4:00 PM - 6:00 PM
New York, NY, US

June 2012

July 2012

Jul 30 - 31
JSM 2012 in San Diego
US

* Council of Chapters International Science and Engineering Fair Breakfast - Monday, 7/30, 7:00 AM - 8:30 AM, Room TBD

* Council of Chapters Governing Board Executive Committee Meeting (closed) - Monday, 7/30, 10:00 AM - 5:00 PM, Room TBD

* Council of Chapters Business Meeting and Breakfast (Chapter Representatives should attend) - Tuesday, 7/31, 7:00 AM - 10:00 AM, Room TBD

* Council of Chapters Traveling Course Committee Meeting - Tuesday, 7/31, 2:00 PM - 3:30 PM, Room TBD

* Council of Chapters Officer Appreciation Reception and Workshop - Tuesday, 7/31, 4:00 PM - 6:00 PM, Room TBD

Joint Statistical Meetings 2012 San Diego, July 28 - August 2
Copyright © 2012 American Statistical Association. All Rights Reserved.